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Monitor Intently (one)mitotane decreases amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Mitotane is usually a strong inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for attainable dosage adjustments.Reserve concomitant prescribing of these drugs in clients for whom